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KMID : 1130320060490101079
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Korean Journal of Pediatrics
2006 Volume.49 No. 10 p.1079 ~ p.1085
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Factors affecting hematologic recovery and infection in high-dose chemotherapy and autologous stem cell transplantation in patients with high-risk solid tumor
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Lee Jung-Hyun
Lee Bo-Lyun
Lee Soo-Hyun
Ryu Kun-Hee
Sung Ki-Woong
Jung Hye-Lim
Cho Eun-Joo
Koo Hong-Hoe
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Abstract
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Purpose:The purpose of this study was to evaluate factors affecting hematologic recovery and infection in high-dose chemotherapy(HDCT) and autologous stem cell transplantation(ASCT) in patients with high-risk solid tumor
Methods:From January 2004 to December 2005, 72 HDCTs and ASCTs were applied to children with high-risk solid tumor at Samsung Medical Center. Medical records of these 72 HDCTs and ASCTs were retrospectively analyzed.
Results:The single most powerful predictor of neutrophil and platelet recovery was the number of transplanted CD34+ cells. The duration of high fever was significantly longer in young patients, in patients treated with total body irradiation and/or thiotepa, and in patients transplanted with lower CD34+ cell dose(<2x10(6)/kg). However, the difference in the duration of high fever according to the number of CD34+ cells was not clinically significant.
Conclusion:Findings in this study suggest that HDCT and ASCT with low CD34+ cell dose is clinically feasible despite delayed hematologic recovery, especially at a dose >1x10(6)/kg per transplantation. Therefore, it is important not to defer the appropriate time for HDCT for an additional collection of hematopoietic stem cells if the number of collected CD34+ cells is >1x10(6)/kg per transplantation
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KEYWORD
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High-dose chemotherapy, Autologous hematopoietic stem cell transplantation, Pediatric solid tumor
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